The research in Mecinovic group applies chemical principles and techniques to understand the underlying molecular origin of fundamental biomolecular processes that play essential roles in human health and disease. Our research is primarily aimed at unravelling the chemical basis of epigenetics, by providing a comprehensive, atomic level understanding of biomolecular recognition and biocatalysis involved in vital epigenetic gene regulation processes.
We are developing new chemical tools for basic molecular studies on widespread posttranslational modifications on histones and other proteins. Building on basic understanding of protein modifications, the group is developing a new generation of inhibitors of biomedically important epigenetic enzymes. All our research projects involve interesting chemistry targeted to understanding biology.
