2024
112. Examining prestructured β-actin peptides as substrates of histidine methyltransferase SETD3; M. N. Maas, N. Bilgin, L. Moesgaard, J. C. J. Hintzen, A. Drozak, J. Drozak, J. Kongsted, J. Mecinović; Sci. Rep. 2024, 14, 26439.
111. Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7; N. Bilgin, A. Tumber, S. Dhingra, E. Salah, A. Al-Salmy, S. Pinzón Martín, Y. Wang, C. J. Schofield, J. Mecinović; Protein Sci. 2024, 33, e5162.
110. Peptide-based inhibitors of epigenetic proteins; J. C. J. Hintzen, J. Mecinović; Prog. Mol. Biol. Transl. Sci. 2024, In Press.
109. Top-down ion mobility/mass spectrometry reveals enzyme specificity: Separation and sequencing of isomeric proteoforms; F. Berthias, N. Bilgin, J. Mecinović, O. N. Jensen; Proteomics 2024, 24, 2200471.
2023
108. (R)-PFI-2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7; M. R. B. Porzberg, D. C. Lenstra, E. Damen, R. H. Blaauw, F. P. J. T. Rutjes, A. Wegert, J. Mecinović; ChemMedChem 2023, 18, e2023004. (plus front cover)
107. Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase; N. Bilgin, V. A. Türkmen, N. Hammami, N. R. Christensen, J. C. J. Hintzen, J. Mecinović; Bioorg. Med. Chem. 2023, 95, 117500.
106. The Role of Trp79 in β-actin on Histidine Methyltransferase SETD3 Catalysis; M. S. Q. Al-Fakhar, N. Bilgin, L. Moesgaard, A. Witecka, J. Drozak, J. Kongsted, J. Mecinović; ChemBioChem 2023, 24, e202300490.
105. Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism; R. E. van Outersterp, P. C. Kooijman, J. Merx, U. F. H. Engelke, N. Omidikia, M.-L. H. Tonneijck, K. J. Houthuijs, G. Berden, T. M. A. Peters, D. J. Lefeber, M. A. A. P. Willemsen, J. Mecinović, J. J. Jansen, K. L. M. Coene, R. A. Wevers, T. J. Boltje, J. Oomens, J. Martens; Anal. Chem. 2023, 95, 9787-9796.
104. Synthetic cysteine-based tools for probing protein posttranslational modifications; J. C. J. Hintzen, J. Mecinović; Tetrahedron Lett. 2023, 124, 154602.
103. Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain; N. Bilgin, L. Moesgaard, M. M. Rahman, V. A. Türkmen, J. Kongsted, J. Mecinović; Int. J. Mol. Sci. 2023, 24, 7002.
102. Probing Polar−π Interactions Between Tetrazoles and Aromatic Rings; J. Jian, R. Hammink, P. Tinnemans, F. M. Bickelhaupt, J. Poater, J. Mecinović; Chem. Asian J. 2023, 18, e202300192.
101. Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66; V. A. Türkmen, J. C. J. Hintzen, A. Tumber, L. Moesgaard, E. Salah, J. Kongsted, C. J. Schofield, J. Mecinović; RSC Chem. Biol. 2023, 4, 235-243.
2022
100. Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins; P. Betlem, M. N. Maas, J. Middelburg, B. J. G. E. Pieters, J. Mecinović; Chem. Commun. 2022, 58, 12196-12199.
99. Investigation of in vitro histone H3 glycosylation using H3 tail peptides; J. Merx, J. C. J. Hintzen, G. Proietti, H. Elferink, Y. Wang, M. R. B. Porzberg, D. Sondag, N. Bilgin, J. Park, J. Mecinović, T. J. Boltje; Sci. Rep., 2022 12, 19251.
98. Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II; J. Merx, R. E. van Outersterp, U. F. H. Engelke, V. Hendriks, R. A. Wevers, M. C. D. G. Huigen, H. W. A. H. Waterval, I. M. L. W. Körver-Keularts, J. Mecinović, F. P. J. T. Rutjes, J. Oomens, K. L. M. Coene, J. Martens, T. J. Boltje; Commun. Biol. 2022, 5, 997.
97. Through-Space Stabilization of an Imidazolium Cation by Aromatic Rings; J. Jian, D. Barkhatova, R. Hammink, P. Tinnemans, F. M. Bickelhaupt, J. Poater, J. Mecinović; J. Org. Chem. 2022, 87, 7875-7883.
96. Probing lysine posttranslational modifications by unnatural amino acids; M. N. Maas, J. C. J. Hintzen, J. Mecinović; Chem. Commun. 2022, 58, 7216-7231.
95. Probing Noncovalent Interactions in [3,3]Metaparacyclophanes; J. Jian, R. Hammink, P. Tinnemans, F. M. Bickelhaupt, C. J. McKenzie, J. Poater, J. Mecinović; J. Org. Chem. 2022, 87, 6087-6096.
94. Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin; J. C. J. Hintzen, H. Ma, H. Deng, A. Witecka, S. B. Andersen, J. Drozak, H. Guo, P. Qian, H. Li, J. Mecinović; Protein Sci. 2022, 31, e4305.
93. Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins; R. Belle, J. J. A. G. Kamps, J. Poater, K. Kumar, B. J. G. E. Pieters, E. Salah, T. D. W. Claridge, R. S. Paton, F. M. Bickelhaupt, A. Kawamura, C. J. Schofield, J. Mecinović; Commun. Chem. 2022, 5, 27.
92. Importance of Ile71 in β-actin on histidine methyltransferase SETD3 catalysis; N. Bilgin, L. Moesgaard, M. N. Maas, J. C. J. Hintzen, A. Witecka, J. Drozak, J. Kongsted, J. Mecinović; Org. Biomol. Chem. 2022, 20, 1723-1730.
91. Recognition of Dimethylarginine Analogues by Tandem Tudor Domain Protein Spindlin1; M. R. B. Porzberg, L. Moesgaard, C. Johansson, U. Oppermann, J. Kongsted, J. Mecinović; Molecules 2022, 27, 983.
90. Probing the Lewis Acidity of Boronic Acids through Interactions with Arene Substituents; J. Jian, R. Hammink, C. J. McKenzie, F. M. Bickelhaupt, J. Poater, J. Mecinović; Chem. Eur. J. 2022, 28, e202104044.
89. Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy; J. Merx, K. J. Houthuijs, H. Elferink, E. Witlox, J. Mecinović, J. Oomens, J. Martens, T. J. Boltje, F. P. J. T. Rutjes; Chem. Eur. J. 2022, 28, e202104078.
88. Amide-Derived Lysine Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferases and Acetyltransferases; J. C. J. Hintzen, J. Merx, M. N. Maas, S.G.H.A. Langens, P. B. White, T. J. Boltje, J. Mecinović; Org. Biomol. Chem. 2022, 20, 173-181.
2021
87. Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy; R. E. van Outersterp, U. F.H. Engelke, J. Merx, G. Berden, M. Paul, T. Thomulka, A. Berkessel, M. C.D.G. Huigen, L. A.J. Kluijtmans, J. Mecinović, F. P.J.T. Rutjes, C. D.M. van Karnebeek, R. A. Wevers, T. J. Boltje, K. L.M. Coene, J. Martens, J. Oomens; Anal. Chem. 2021, 93, 15340–15348.
86. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy; U. F. G. Engelke, R. E. van Outersterp, J. Merx, F. A. M. G. van Geenen, A. van Rooij, G. Berden, M. C. D. G. Huigen, L. A. J. Kluijtmans, T. M. A. Peters, H. H. Al-Shekaili, B. R. Leavitt, E. de Vrieze, S. Broekman, E. van Wijk, L. A. Tseng, P. Kulkarni, F. P. J. T. Rutjes, J. Mecinović, E. A. Struys, L. A. Jansen, S. M. Gospe, Jr., S. Mercimek-Andrews, K. Hyland, M. A. A. P. Willemsen, L. A. Bok, C. D. M. van Karnebeek, R. A. Wevers, T. J. Boltje, J. Oomens, J. Martens, K. L. M. Coene; J. Clin. Invest. 2021, 131(15):e148272.
85. γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases; J. C. J. Hintzen, Y. Luo, M. R. B. Porzberg, P. B. White, J. Jian, G. Proietti, J. Mecinović; Chem. Commun. 2021, 57, 6788-6791.
84. β-Actin Peptide-Based Inhibitors of Histidine Methyltransferase SETD3; J. C. J. Hintzen, L. Moesgaard, S. Kwiatkowski, J. Drozak, J. Kongsted, J. Mecinović; ChemMedChem 2021, 16, 2695–2702.
83. Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides; M. N. Maas, J. C. J. Hintzen, P. M. G. Löffler, J. Mecinović; Chem. Commun. 2021, 57, 3283-3286.
82. Substrate Scope for Human Histone Lysine Acetyltransferase KAT8; G. Proietti, Y. Wang, C. Punzo, J. Mecinović; Int. J. Mol. Sci. 2021, 22, 846.
81. Do sulfonamides interact with aromatic rings?; J. Jian, R. Hammink, C. J. McKenzie, F. M. Bickelhaupt, J. Poater, J. Mecinović; Chem. Eur. J. 2021, 27, 5721-5729.
2020
80. Trimethyllysine: From Carnitine Biosynthesis to Epigenetics; M. N. Maas, J. C. J. Hintzen, M. R. B. Porzberg, J. Mecinović; Int. J. Mol. Sci. 2020, 21, 9451.
79. Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases; A. H. K. Al Temimi, J. Merx, C. J. van Noortwijk, G. Proietti, R. Buijs, P. B. White, F. P. J. T. Rutjes, T. J. Boltje, J. Mecinović; Sci. Rep. 2020, 10, 21574.
78. Probing Halogen–π versus CH–π Interactions in Molecular Balance. J. Jian, J. Poater, P. B. White, C. J. McKenzie, F. M. Bickelhaupt, J. Mecinović; Org. Lett. 2020, 22, 7870-7873.
77. Effect of lysine side chain length on histone lysine acetyltransferase catalysis. G. Proietti, Y. Wang, G. Rainone, J. Mecinović; Sci. Rep. 2020, 10, 13046.
76. Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger. B. J. G. E. Pieters, M. H. M. Wuts, J. Poater, K. Kumar, P. B. White, J. J. A. G. Kamps, W. Sherman, G. J. M. Pruijn, R. S. Paton, T. Beuming, F. M. Bickelhaupt, J. Mecinović; Commun. Chem. 2020, 3, 69.
75. Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins. J. C. J. Hintzen, J. Poater, K. Kumar, A. H. K. Al Temimi, B. J. G. E. Pieters, R. S. Paton, F. M. Bickelhaupt, J. Mecinović; Molecules 2020, 25, 1918.
74. Through-Space Polar–π Interactions in 2,6-Diarylthiophenols. J. Jian, J. Poater, R. Hammink, P. Tinnemans, C. J. McKenzie, F. M. Bickelhaupt, J. Mecinović; ChemPhysChem 2020, 11, 1092-1100. (plus profile cover and front cover)
73. Exploring the Histone Acylome through Incorporation of γ-Thialysine on Histone Tails. G. Proietti, G. Rainone, J. C. J. Hintzen, J. Mecinović; Bioconjugate Chem. 2020, 31, 844-851.
72. Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases. A. H. K. Al Temimi, P. B. White, M. J. M. Mulders, N. G. A. van der Linden, R. H. Blaauw, A. Wegert, F. P. J. T. Rutjes, J. Mecinović; Chem. Commun. 2020, 56, 3039-3042
71. Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis. A. H. K. Al Temimi, V. Tran, R. S. Teeuwen, A. J. Altunc, H. I. V. Amatdjais-Groenen, P. B. White, D. C. Lenstra, G. Proietti, Y. Wang, A. Wegert, R. H. Blaauw, P. Qian, W. Ren, H. Guo, J. Mecinović; Sci. Rep. 2020, 10, 3671.
70. Lysine Ethylation by Histone Lysine Methyltransferases; A. H. K. Al Temimi, M. Martin, Q. Meng, D. C. Lenstra, P. Qian, H. Guo, E. Weinhold, J. Mecinović; ChemBioChem 2020, 21, 392-400.
2019
69. The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis; A. H. K. Al Temimi, H. I. V. Amatdjais-Groenen, Y. V. Reddy, R. H. Blaauw, H. Guo, P. Qian, J. Mecinović; Commun. Chem. 2019, 2, 112.
68. Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2; R. Leenders, R. Zijlmans, B. van Bree, M. van de Sande, F. Trivarelli, E. Damen, A. Wegert, D. Müller, J. E. Ehlert, D. Feger, C. Heidemann-Dinger, M. Kubbutat, C. Schächtele, D. C. Lenstra, J. Mecinović, G. Müller; Bioorg. Med. Chem. Lett. 2019, 29, 2516-2524.
67. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations; M. J. Sánchez-Fernández, M. R. Immers, R. P. Félix Lanao, F. Yang, J. C. M. E. Bender, J. Mecinović, S. C. G. Leeuwenburgh, J. C. M. van Hest; Biomacromolecules 2019, 20, 2913-2921
66. γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones. A. H. K. Al Temimi, R. van der Wekken-de Bruijne, G. Proietti, H. Guo, P. Qian, J. Mecinović; Bioconjugate Chem. 2019, 30, 1798-1804.
65. Importance of the main chain of lysine for histone lysine methyltransferase catalysis; A. H. K. Al Temimi, R. S. Teeuwen, V. Tran, A. J. Altunc, D. C. Lenstra, W. Ren, P. Qian, H. Guo, J. Mecinović; Org. Biomol. Chem. 2019, 17, 5693-5697.
64. Catalytic Staudinger Reduction at Room Temperature; D. C. Lenstra, J. J. Wolf, J. Mecinović; J. Org. Chem. 2019, 84, 6536-6545.
63. Investigating the active site of human trimethyllysine hydroxylase; Y. Wang, Y. V. Reddy, A. H. K. Al Temimi, H. Venselaar, F. H. T. Nelissen, D. C. Lenstra, J. Mecinović; Biochem. J. 2019, 476, 1109-1119.
62. Biomolecular Recognition of Methylated Histones; M. R. B. Porzberg, B. J. G. E. Pieters, J. Mecinović; In The DNA, RNA, and Histone Methylomes, Springer Nature, 2019, 435-451.
61. Catalytic transport of molecular cargo using diffusive binding along a polymer track; L. Zheng, H. Zhao, Y. Han, H. Qian, L. Vukovic, J. Mecinović, P. Kral, W. T. S. Huck; Nat. Chem. 2019, 11, 359-366.
60. Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation; B. J. G. E. Pieters, J. C. J. Hintzen, Y. Grobben, A. H. K. Al Temimi, J. J. A. G. Kamps, J. Mecinović; Bioconjugate Chem. 2019, 30, 952-958.
59. Probing Through-Space Polar−π Interactions in 2,6-Diarylphenols; V. Bosmans, J. Poater, R. Hammink, P. Tinnemans, F. M. Bickelhaupt, J. Mecinović; J. Org. Chem. 2019, 84, 3632-3637.
58. Mechanistic Insight into the Catalytic Staudinger Ligation; P. B. White, S. J. Rijpkema, R. P. Bunschoten, J. Mecinović; Org. Lett. 2019, 21, 1011-1014.
57. Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture; J. T. Bush, R. K. Lesniak, Y.-L. Yeh, R. Belle, H. Kramer, A. Tumber, R. Chowdhury, E. Flashman, J. Mecinović, C. J. Schofield; Chem. Commun. 2019, 55, 1020-1023. (plus front cover)
2018
56. Sustainable Organophosphorus-Catalysed Staudinger Reduction; D. C. Lenstra, P. E. Lenting, J. Mecinović; Green Chem. 2018, 20, 4418-4422.
55. Structure-Activity Relationship Studies on (R)-PFI-2 Analogs as Inhibitors of Histone Lysine Methyltransferase SETD7; D. C. Lenstra, E. Damen, R. G. G. Leenders, R. H. Blaauw, F. P. J. T. Rutjes, A. Wegert, J. Mecinović; ChemMedChem 2018, 13, 1405-1413.
54. Like Heterochromatin Protein 1 partners with ATRX through unique domains to assist Polycomb Repressive Complex 2 function in plants; H. Wang, D. Jiang, E. Axelsson, S. Montgomery, S. Holec, B. J. G. E. Pieters, A. H. K. Al Temimi, J. Mecinović, F. Berger; Mol. Plant 2018, 11, 1038-1052.
53. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2; M. I. Abboud, T. E. McAllister, I. K. H. Leung, R. Chowdhury, C. Jorgensen, C. Domene, J. Mecinović, K. Lippl, R. L. Hancock, R. J. Hopkinson, A. Kawamura, T. D. W. Claridge, C. J. Schofield; Chem. Commun. 2018, 54, 3130-3133.
52. Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II); D. C. Lenstra, A. H. K. Al Temimi, J. Mecinović; Bioorg. Med. Chem. Lett. 2018, 28, 1234-1238.
51. Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins; A. H. K. Al Temimi, R. Belle, K. Kumar, J. Poater, P. Betlem, B. J. G. E. Pieters, R. S. Paton, F. M. Bickelhaupt, J. Mecinović; Chem. Commun. 2018, 54, 2409-2412.
2017
50. Investigating D-Lysine Stereochemistry for Epigenetic Methylation, Demethylation and Recognition; R. Belle, A. H. K. Al Temimi, K. Kumar, B. J. G. E. Pieters, A. Tumber, J. E. Dunford, C. Johansson, U. Oppermann, T. Brown, C. J. Schofield, R. J. Hopkinson, R. S. Paton, A. Kawamura, J. Mecinović; Chem. Commun. 2017, 53, 13264-13267.
49. Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis; A. H. K. Al Temimi, Y. V. Reddy, P. B. White, H. Guo, P. Qian, J. Mecinović; Sci. Rep. 2017, 7, 16148.
48. Stabilization of 2,6-Diarylanilinum Cation by Through-Space Cation–π Interactions; J. Simó Padial, J. Poater, D. T. Nguyen, P. Tinnemans, F. M. Bickelhaupt, J. Mecinović; J. Org. Chem. 2017, 82, 9418-9424.
47. Polymethylhydrosiloxane as a Green Reducing Agent in Organophosphorus-Catalysed Amide Bond Formation; D. F. J. Hamstra, D. C. Lenstra, T. Koenders, F. P. J. T. Rutjes, J. Mecinović; Org. Biomol. Chem. 2017, 15, 6426-6432.
46. Fluorinated Trimethyllysine as a 19F NMR Probe for Trimethyllysine Hydroxylase Catalysis; Y. V. Reddy, A. H. K. Al Temimi, J. Mecinović; Org. Biomol. Chem. 2017, 15, 1350-1354.
45. Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine; Y. V. Reddy, A. H. K. Al Temimi, P. B. White, J. Mecinović; Org. Lett. 2017, 19, 400-403.
2016
44. Substrate Scope for Trimethyllysine Hydroxylase Catalysis; A. H. K. Al Temimi, B. J. G. E. Pieters, Y. V. Reddy, P. B. White, J. Mecinović; Chem. Commun. 2016, 52, 12849-12852.
43. Multicolor Photoluminescence Including White-Light Emission by a Single Host-Guest Complex; Q.-W. Zhang, D. Li, X. Li, P. B. White, J. Mecinović, X. Ma, H. Ågren, R. J. M. Nolte, H. Tian; J. Am. Chem. Soc. 2016, 138, 13541-13550.
42. Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis; J. J. A. G. Kamps, A. Khan, H. Choi, R. K. Lesniak, J. Brem, A. M. Rydzik, M. A. McDonough, C. J. Schofield, T. D. W. Claridge, J. Mecinović; Chem. Eur. J. 2016, 22, 1270-1276 (plus frontispiece, hot article)
41. Natural Supramolecular Protein Assemblies; B. J. G. E. Pieters, M. B. van Eldijk, R. J. M. Nolte, J. Mecinović; Chem. Soc. Rev. 2016, 45, 24-39. (hot article)
2015
40. Chemical Basis for the Recognition of Trimethyllysine by Epigenetic Reader Proteins; J. J. A. G. Kamps, J. Huang, J. Poater, C. Xu, B. J. G. E. Pieters, A. Dong, J. Min, W. Sherman, T. Beuming, F. M. Bickelhaupt, H. Li, J. Mecinović; Nat. Commun. 2015, 6, 8911.
39. Chemoselective Calcium-Catalysed Direct Amidation of Carboxylic Esters; D. T. Nguyen, D. C. Lenstra, J. Mecinović; RSC Adv. 2015, 5, 77658-77661.
38. The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain; B. J. G. E. Pieters, E. Meulenbroeks, R. Belle, J. Mecinović; PLoS One 2015, 10, e0139205.
37. Zirconium-Catalysed Amide Bond Formation Between Carboxylic Esters and Amines; D. C. Lenstra, D. T. Nguyen, J. Mecinović; Tetrahedron 2015, 71, 5547-5553.
2014
36. Transmission Electron Microscopy Enables the Reconstruction of the Catenane and Ring Forms of CS2 Hydrolase; J. C. Wang, A. Zlotnick, J. Mecinović; Chem. Commun. 2014, 50, 10281-10283.
35. Catenane versus Ring: Do both Assemblies of CS2 Hydrolase Exhibit the same Stability and Catalytic Activity?; M. B. van Eldijk, B. J. Pieters, V. A. Mikhailov, C. V. Robinson, J. C. M. van Hest, J. Mecinović; Chem. Sci. 2014, 5, 2879-2884.
34. Stabilisation of 2,6-Diarylpyridinium Cation by Through-Space Polar-π Interactions; J. Simó Padial, R. de Gelder, C. Fonseca Guerra, F. M. Bickelhaupt, J. Mecinović; Chem. Eur. J. 2014, 20, 6268-6271.
33. Triphenylphosphine-catalysed Amide Bond Formation Between Carboxylic Acids and Amines; D. C. Lenstra, F. P. J. T. Rutjes, J. Mecinović; Chem. Commun. 2014, 50, 5763-5766.
32. Thermodynamic Investigation of Z33-Antibody Interaction Leads to Selective Purification of Human Antibodies; M. B. van Eldijk, F. C. M. Smits, J. C. Thies, J. Mecinović, J. C. M. van Hest; J. Biotechnol. 2014, 179, 32-41.
2013
31. The Effect of the Length of Histone H3K4me3 on the Recognition by Reader Proteins; B. Pieters, R. Belle, J. Mecinović; ChemBioChem 2013, 18, 2408-2412.
30. Evidence That the Catenane Form of CS2 Hydrolase is not an Artefact; M. B. van Eldijk, I. van Leeuwen, V. A. Mikhailov, L. Neijenhuis, H. R. Harhangi, J. C. M. Van Hest, M. S. M. Jetten, H. J. M. Op den Camp, C. V. Robinson, J. Mecinović; Chem. Commun. 2013, 49, 7770-7772. (plus inside front cover, hot article)
29. Hydroxylamine as an Oxygen Nucleophile: Substitution of Sulfonamide by Hydroxyl Group in Benzothiazole-2-sulfonamides; J. J. A. G. Kamps, R. Belle, J. Mecinović; Org. Biomol. Chem. 2013, 11, 1103-1108. (plus inside front cover)
28. Dual-Action Inhibitors of HIF Prolyl Hydroxylases That Induce Binding of a Second Iron Ion; K. K. Yeoh, M. C. Chan, A. Thalhammer, M. Demetriades, R. Chowdhury, Y. M. Tian, I. Stolze, L. A. McNeill, M. K. Lee, E. C. Y. Woon, M. M. Mackeen, A. Kawamura, P. J. Ratcliffe, J. Mecinović, C. J. Schofield; Org. Biomol. Chem. 2013, 11, 732-745. (plus inside front cover)
2012
27. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams; R. B. Hamed, L. Henry, J. R. Gomez-Castellanos, J. Mecinović, C. Ducho, J. L. Sorensen, T. D. W. Claridge, C. J. Schofield; J. Am. Chem. Soc. 2012, 134, 471-479.
2011
26. Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model; D. J. S. Kelly, A. C. Morton, N. D. Arnold, J. Mecinović, C. J. Schofield, H. Lupton, K. Al-Lamee, D. C. Crossman, J. Gunn, A. Gershlick; J. Clin. Experiment. Cardiol. 2011, 2, 148.
25. Mechanism of the Hydrophobic Effect in the Biomolecular Recognition of Arylsulfonamides by Carbonic Anhydrase; P. W. Snyder, J. Mecinović, D. T. Moustakas, S. W. Thomas III, M. Harder, E. T. Mack, M. R. Lockett, A. Héroux, W. Sherman, G. M. Whitesides; Proc. Natl. Acad. Sci. USA. 2011, 108, 17889-17894.
24. Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the ‘‘Hydrophobic Wall’’ of Carbonic Anhydrase; J. Mecinović, P. W. Snyder, K. A. Mirica, S. Bai, E. T. Mack, R. L. Kwant, D. T. Moustakas, A. Heroux, and G. M. Whitesides; J. Am. Chem. Soc. 2011, 133, 14017-14026.
23. Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1); R. Chowdhury, E. Flashman, J. Mecinović, H. B. Kramer, B. M. Kessler, Y. M. Frapart, J. L. Boucher, I. J. Clifton, M. A. McDonough, C. J. Schofield; J. Mol. Biol. 2011, 410, 268-279.
22. Inhibition of Histone Demethylase JMJD2E by 3-Substituted Pyridine 2,4-Dicarboxylates; A. Thalhammer, J. Mecinović, C. Loenarz, A. Tumber, N. R. Rose, T. D. Heightman, C. J. Schofield; Org. Biomol. Chem. 2011, 9, 127-135.
2010
21. 2-Oxoglutarate Oxygenases Are Inhibited By A Range Of Transition Metals; R. Sekirnik, N. R. Rose, J. Mecinović, C. J. Schofield; Metallomics 2010, 2, 397-399.
20. Carboxymethylproline Synthase Catalysed Syntheses of Functionalised N-Heterocycles; R. B. Hamed, J. Mecinović, C. Ducho, T. D. W. Claridge, C. J. Schofield; Chem. Commun. 2010, 46, 1413-1415. (hot paper)
19. Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches; N. R. Rose, E. C. Y. Woon, G. L. Kingham, O. N. F. King, J. Mecinović, I. J. Clifton, S. S. Ng, J. Talib-Hardy, U. Oppermann, M. A. McDonough, C. J. Schofield; J. Med. Chem. 2010, 53, 1810-1818.
18. Therapeutic Manipulation of the HIF Hydroxylases; S. Nagel, N. P. Talbot, J. Mecinović, T. G. Smith, A. M. Buchan, C. J. Schofield; Antiox. Redox Signal. 2010, 12, 481-501. (plus front cover)
2009
17. Inhibition of Histone Lysine Demethylase JMJD2A by Ejection of Structural Zn(II); R. Sekirnik, N. R. Rose, A. Thalhammer, P. T. Seden, J. Mecinović, C. J. Schofield; Chem. Commun. 2009, 42, 6376-6378. (hot paper)
16. 2-Oxoglutarate Analogue Inhibitors of Prolyl Hydroxylase Domain 2; J. Mecinović, C. Loenarz, R. Chowdhury, C. J. Schofield; Bioorg. Med. Chem. Lett. 2009, 19, 6192-6195.
15. A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene; C. Church, S. Lee, E. A. L. Bagg, J. S. McTaggart, R. Deacon, T. Gerken, A. Lee, L. Moir, J. Mecinović, M. M. Quwailid, C. J. Schofield, F. M. Ashcroft, R. D. Cox; PLoS Genetics 2009, 5, e1000599.
14. Epidithiodiketopiperazines Block the Interaction Between Hypoxia Inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism; K. M. Cook, S. T. Hilton, J. Mecinović, W. B. Motherwell, W. D. Figg, C. J. Schofield; J. Biol. Chem. 2009, 284, 26831-26838.
13. Use of Mass Spectrometry to Probe the Nucleophilicity of Cysteinyl-Residues of Prolyl Hydroxylase Domain 2; J. Mecinović, R. Chowdhury, E. Flashman, C. J. Schofield; Anal. Biochem. 2009, 393, 215-221.
12. Stuctural Basis for Binding of Hypoxia-Inducible Factor by the Oxygen Sensing Prolyl Hydroxylases; R. Chowdhury, M. A. McDonough, J. Mecinović, C. Loenarz, E. Flashman, K. S. Hewitson, C. Domene, C. J. Schofield; Structure 2009, 17, 981-989. (plus front cover)
11. Direct Analysis of Enzyme-Catalyzed DNA Demethylation; A. A. Karkhanina, J. Mecinović, M. U. Musheev, S. M. Krylova, A. P. Petrov, K. S. Hewitson, E. Flashman, C. J. Schofield, S. N. Krylov; Anal. Chem. 2009, 81, 5871-5875.
10. Application of a Proteolysis/Mass Spectrometry Method For Investigating the Effects of Inhibitors on Hydroxylase Structure; C. J. Stubbs, C. Loenarz, J. Mecinović, K. K. Yeoh, N. Hindley, B. M. Liénard, F. Sobott, C. J. Schofield, E. Flashman; J. Med. Chem. 2009, 52, 2799-2805.
9. Iron-Mediated Cleavage of C-C Bonds in Vicinal Tricarbonyl Compounds in Water; J. Mecinović, R. B. Hamed, C. J. Schofield; Angew. Chem. Int. Ed. 2009, 48, 2796-2800. (hot paper)
8. Evidence for a Stereoelectronic Effect in Human Oxygen Sensing; C. Loenarz, J. Mecinović, R. Chowdhury, L. A. McNeill, E. Flashman, C. J. Schofield; Angew. Chem. Int. Ed. 2009, 48, 1784-1787.
7. Triflic Anhydride-Mediated Synthesis of Oxazoles; A. Thalhammer, J. Mecinović, C. J. Schofield; Tetrahedron Lett. 2009, 50, 1045-1047.
6. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline; R. B. Hamed, E. T. Batchelar, J. Mecinović, T. D. W. Claridge, C. J. Schofield; ChemBioChem 2009, 10, 246-250. (plus front cover)
2008
5. Inhibitor Scaffolds for the 2-Oxoglutarate-Dependent Histone Lysine Demethylases; N. R. Rose, S. S. Ng, J. Mecinović, B. M. R. Liénard, S. H. Bello, Z. Sun, M. A. McDonough, U. Oppermann, C. J. Schofield; J. Med. Chem. 2008, 51, 7053-7056.
4. ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site; J. Mecinović, R. Chowdhury, B. M. R. Liénard, E. Flashman, M. R. G. Buck, N. J. Oldham, C. J. Schofield; ChemMedChem 2008, 3, 569-572. (plus front cover)
3. Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases; E. Flashman, E. A. L. Bagg, R. Chowdhury, J. Mecinović, C. Loenarz, M. A. McDonough, K. S. Hewitson, C. J. Schofield; J. Biol. Chem. 2008, 283, 3808-3815.
2007
2. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor; M. L. Coleman, M. A. McDonough, K. S. Hewitson, C. Coles, J. Mecinović, M. Edelmann, K. M. Cook, M. E. Cockman, D. E. Lancaster, B. M. Kessler, N. J. Oldham, P. J. Ratcliffe, C. J. Schofield; J. Biol. Chem. 2007, 282, 24027-24038.
2006
1. 3-(Dimethylamino)propenoate-Based Regioselective Synthesis of 1,4-Disubstituted 5-Hydroxy-1H-Pyrazoles; D. Kralj, J. Mecinović, D. Bevk, U. Grošelj, B. Stanovnik, J. Svete; Heterocycles 2006, 68, 897-914.