2024
All-cause mortality and cause-specific death in U.S. long-lived siblings: data from the Long Life Family Study
Yao S, Boudreau RM, Galvin A, Marubito JM, Honig LS, Perls TT, Christensen K, Newman AB.
Gerontol A Biol Sci Med Sci. 2024 Nov;79(11). Pubmed abstract
Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study
Santanasto AJ, Acharya S, Wojczynski MK, Cvejkus RK, Lin S, Brent MR, Anema JA, Wang L, Thyagarajan B, Christensen K, Daw EW, Zmuda JM.
J Gerontol Biol Sci Med Sci. 2024 Aug; 79(8): glae144. Pubmed abstract
Discovery of genome and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta-analyses: The Long Life Family Study
Feitosa MF, Lin SJ, Acharya S, Thyagarajan B, Wojczynski MK, Kuipers AL, Kulminski A, Christensen K, Zmuda JM, Brent MR, Province M.
Aging Cell. 2024 Oct;23(10):e14261. Pubmed abstract
End of Life Events and Causes of Death in Danish Long-Lived Siblings: Reduced Dementia Risk Compared to Sporadic Long-Livers
Galvin A, Pedersen JK, Arbeev KG, Feitosa MF, Ukraintseva S, Yao S, Newman AB, Christensen K.
J Alzheimers Dis. 2024 Jun; 99(4):1397-1407. Pubmed abstract
Developmental origins of exceptional health and survival: A four-generation family cohort study
Keys MT, Pedersen DA, Larsen PS, Kulminski A, Feitosa MF, Wojczynski M, Province M, Christensen K.
medRxiv [Preprint] 2024 May. Pubmed abstract
Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults
Tan Q, Li W, Nygaard M, An P, Feitosa M, Wojczynski MK, Zmuda J, Arbeev K, Ukraintseva S, Yashin A Christensen K, Mengel-From J.
Int J Mol Sci. 2024 May; 25(10):5257. Pubmed abstract
A Novel Gene ARHGAP44 for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (OFF)
Wang S, Lenzini P, Thygarajan B, Lee JH, Vardarajan BN, Yashin A, Miljkovic I Warwick Daw E, Lin SJ, Patti G, Brent M, Zmuda JM, Perls TT, Christensen K, Province MA, An P.
bioRxiv [Preprint] 2024 May. Pubmed abstract
Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS)
Patel R, Cosentino S, Zheng EZ, Schupf N, Barral S, Feitosa M, Andersen SL, Sebastiani P, Ukraintseva S, Christensen K, Zmuda J, Thyagarajan B, Gu Y.
Brain Behav Immun Health. 2024 Feb; 37:100746. Pubmed abstract
The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers
Galvin G, Pedersen JK, Wojczynski MK, Ukraintseva S, Arbeev K, Feitosa M, Province MA, Christensen K.
J Gerontol A Biol Sci Med Sci. 2024 Jan. 79(1):glad164. Pubmed abstract
The association between frailty and perceived physical and mental fatigability: The Long Life Family Study
Schumacher BT, Kehler DS, Kulminski AM, Qiao YS, Andersen SL, Gmelin T, Christensen K, Wojczynski MK, Theou O, Rockwood K, Newman AB, Glynn NW.
J Am Geriatr Soc. 2024 Jan,72(1):219-225. Pubmed abstract
2023
Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease
Arbeev KG, Ukraintseva S, Bagley O, Duan H, Wu D, Akushevish I, Stallard E, Kulminski A, Christensen K, Feitosa MF, O'Connell JR, Parker D, Whitson H, Yashin AI.
Front Genet. 2023 Aug. 14:1236509. Pubmed abstract
Mosaic Chromosomal Alterations and Human Longevity
Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P.
J Gerontol A Biol Sci Med Sci. 2023 Aug. 78(9):1561-1568. Pubmed abstract
A metabolomic signature of the APOE2 allele
Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patto GJ, Perls TT.
Geroscience. 2023 Feb;45(1):415-426. Pubmed abstract
Rare genetic variants correlate with better processing speed
Song Z, Gurinovich A, Nygaard M, Mengel-From J, Andersen S, Cosentino S, Schupf N, Lee J, Zmuda J, Ukraintseva S, Arbeev K, Christensen K, Perls T, Sebastiani P.
Neurobiol Aging. 2023 May. 125:115-122. Pubmed abstract
Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis
Xiang Q, Andersen SL, Sweigart B, Gunn S, Nygaard M, Perls TT, Sebastiani P.
J Alzheimers Dis. 2023;93(4):1457-1469. Pubmed abstract
2022
Association between late maternal age and age-related endophenotypes in the Long Life Family Study
Barral S, Andersen SL, Perls T, Bae H, Sebatiani P, Christensen K, Thyagarajan B, Lee J, Schupf N.
Neurosci Lett. 2022 Jul:784:136737. Pubmed abstract
Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study
Feitosa MF, Wojczynski MK, Anema JA, Daw EW, Wang L, Santanasto AJ, Nygaard M, Province MA.
J Gerontol A Biol Sci Med Sci. 2022 Feb:glac046. Pubmed abstract
Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults
Glynn NW, Gmelin T, Renner SW, Qiao YS, Boudreau RM, Feitosa MF, Wojczynski, Cosentino S, Andersen SL, Christensen K, Newman AB.
J Gerontol A Biol Sci Med Sci. 2022 Apr;77(4):837-841. Pubmed abstract
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring
Gunn S, Wainberg M, Song Z, Andersen S, Boudreau R, Feitosa MF, Tan Q, Montasser ME, O'Connell JR, Stitziel N, Proce N, Perls T, Schork NJ, Sebeastiani P.
Geroscience. 2022 Apr. 44(2):719-729. Pubmed abstract
Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data
Gurinovich A, Li M, Leshchyk A, Bae H, Song Z, Arbeev KG, Nygaard M, Feitosa MF, Perls TT, Sebastiani P.
Front Genet. 2022 Sep. 13:897210. Pubmed abstract
Association of leukocyte telomere length with perceived physical fatigability
Katz R, Gay EL, Kuipers AL, Lee JH, Honig LS, Christensen K, Feitosa MF, Wojczynski M, Glynn NW.
Exp Gerontol. 2022 Dec: 170:111988. Pubmed abstract
Low Risk for Developing Diabetes Among the Offspring of Individuals With Exceptional Longevity and Their Spouses
Miljkovic I, Cvejkus R, An P, Thyagarajan B, Christensen K, Wojczynski M, Schupf N, Zmuda JM.
Front Clin Diabetes Healthc. 2022 Apr. 3:753986. Pubmed abstract
Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study
Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW.
Aging Clin Exp Res. 2022 Feb. 24(2):367-374. Pubmed abstract
NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes
Wojczynski M, Lin SJ, Sebastiani P, Perls TT, Lee J, Kulminski A, Newman A, Zmuda JM, Christensen K, Province MA.
J Gerontol A Biol Sci Med. 2022 Apr. 77(4):717-727. Pubmed abstract
2021
Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior
Andersen SL, Sweigart B, Glynn NW, Wojczynski MK, Thyagarajan B, Mengel-From J, Thielke S, Perls TT, Libon DJ, Au R, Cosentino S, Sebastiani P.
J Alzheimers Dis. 2021;82(1):17-32. Pubmed abstract
Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments
Feitosa MF, Kuipers AL, Wojczynski M, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA.
Circ Genom Prices Med. 2021 Jun. 14(3):e003201. Pubmed abstract
Physical resilience after a diagnosis of cardiovascular disease among offspring of long-lived siblings
Galvin A, Feitosa M, Arbeev K, Kuipers AL, Wojczynski M, Ukrainsteva S, Christensen K.
Eur J Ageing. 2021 Aug. 17;19(3):437-445. Pubmed abstract
Evaluation of the Bidirectional Relations of Perceived Physical Fatigability and Physical Activity on Slower Gait Speed
Qiao YS, Gmelin T, Renner SW, Boudreau RM, Martin S, Wojczynski MK, Christensen K, Andersen SL, Cosentino S, Santanasto AJ, Glynn NW.J Gerontol A Biol Sci Med Sci. 2021 Sep. Pubmed abstract
Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study
Santanasto AJ, Wojczynski MK, Cvejkus RK, Lin S, Wang L, Thyagarajan B, Christensen K, Schupf N, Feitosa MF, An P, Zmuda JM.
J Gerontol A Biol Sci Med Sci. 2021 Sep; 76(10):e307-e313. Pubmed abstract
Circulating Procollagen type III N-terminal peptide (P3NP) and Physical Function in Adults from The Long Life Family Study
Santanasto AJ, Cvejkus RK, Wojczynski MK, Marron MM, Schupf N, Christensen K, Thyagarajan B, Zmuda JM.
J Gerontol A Biol Sci Med Sci. 2021 Jun. Pubmed abstract
Relationship Between Serum IGF-1 and BMI Differs by Age
Sherlala RA, Kammerer CM, Kuipers AL, Wojczynski MK, Ukraintseva SV, Feitosa MF, Mengel-From J, Zmuda JM, Minster RL.
J Gerontol A Biol Sci Med Sci. 2021 Jun;76(7):1303-1308. Pubmed abstract
Genetic association analysis of the cardiovascular biomarker: N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP)
Yang Y, Zmuda JM, Wojczynski MK, Thyagarajan B, Christensen K, Cvejkus RK, Kuipers AL.Pubmed abstract. PLoS One. 2021 Mar. 16(3):e0248726Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults
Yudkovicz JJ, Minster RL, Barinas-Mitchell E, Christensen K, Feitosa M, Barker MS, Newman AB, Kuipers AL.
Sci Rep. 2021 Sep;11(1):17980. Pubmed abstract
2020
Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study
Arbeev KG, Bagley O, Ukraintseva SV, Duan H, Kulminski AM, Stallard E, Wu D, Christensen K, Feitosa MF, Thyagarajan B, Zmuda JM, Yashin AI, Arbeev KG, et al. Front Public Health. 2020 Mar;8:56. Pubmed abstract
Genetics of physiological dysregulation: findings from the long life family study using joint models
Arbeev KG, Bagley O, Ukraintseva SV, Wu D, Duan H, Kulminski AM, Stallard E, Christensen K, Lee JH, Thyagarajan B, Zmuda JM, Yashin AI.Arbeev KG, et al.
Aging (Albany NY). 2020 Apr;12(7):5920-5947. Pubmed abstract
Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants
Ashrafi A, Cosentino S, Kang MS, Lee JH, Schupf N, Andersen SL, Christensen K, Province MA, Thyagarajan B, Zmuda JM, Honig LS, Ashrafi A, et al.
J Int Neuropsychol Soc. 2020 Oct;26(9):906-917. Pubmed abstract
Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study
Christensen K, Wojczynski MK, Pedersen JK, Larsen LA, Klojgaard S, Skytthe A, McGue M, Vaupel JW, Province MA.
Aging Cell. 2020 Oct;19(10):e13228. Pubmed abstract
Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies
Feitosa MF, Lunetta KL, Wang L, Wojczynski MK, Kammerer CM, Perls T, Schupf N, Christensen K, Murabito JM, Province MA.
Atherosclerosis. 2020 Mar;297:102-110. Pubmed abstract
Physical robustness and resilience among long-lived female siblings: a comparison with sporadic long-livers
Galvin A, Ukraintseva S, Arbeev K, Feitosa M, Christensen K.
Aging (Albany NY). 2020 Jul. 12(14):15157-15168. Pubmed abstract
Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study
LaSorda KR, Gmelin T, Kuipers AL, Boudreau RM, Santanasto AJ, Christensen K, Renner SW, Wojczynski MK, Andersen SL, Cosentino S, Glynn NW; LLFS Research Group.
J Gerontol A Biol Sci Med Sci. 2020 Sep;75(9):e81-e88. Pubmed abstract
Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study
Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Nicole Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. J Gerontol A Biol Sci Med Sci. 2020 Apr; 17(5):899-905. Pubmed abstractPatterns of multi-domain cognitive aging in participants of the Long Life Family Study
Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT.
Geroscience. 2020 Oct;42(5):1335-1350. Pubmed abstract
2019
Independent associations of TOMM40 and APOE variants with body mass index
Kulminski AM, Loika Y, Culminskaya I, Huang J, Arbeev KG, Bagley O, Feitosa MF, Zmuda JM, Christensen K, Yashin AI; Long Life Family Study Research Group.
Aging Cell. 2019 Feb;18(1):e12869. Pubmed abstract
Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism
Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB.
Geroscience. 2019 Aug;41(4):383-393. Pubmed abstract
A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity
Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB; Long Life Family Study.
Metabolism. 2019 May;94:28-38. Pubmed abstract
APOE Alleles and Extreme Human Longevity
Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT.
J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. Pubmed abstract
2018
Genetics of cumulative measure of physiological dysregulation: Evidence from Long Life Family Study
Arbeev K, Bagley O, Ukraintseva SV, Thyagarajan B, Zmuda JM, Lee JH, Christensen K, Yashin AI.
Innov Aging. 2018 Nov; 2(Suppl 1): 405. Pubmed abstract
The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study
Kulminski AM, Barochia AV, Loika Y, Raghavachari N, Arbeev KG, Wojczynski MK, Thyagarajan B, Vardarajan BN, Christensen K, Yashin AI, Levine SJ.
PLoS One. 2018 Nov;13(11):e0206873. Pubmed abstract
A novel healthy blood pressure phenotype in the Long Life Family Study
Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB.
J Hypertens. 2018 Jan;36(1):43-53. Pubmed abstract
Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV.
J Gerontol A Biol Sci Med Sci. 2018 Oct;73(11):1472-1481. Pubmed abstract
2017
Age-related biomarkers in LLFS families with exceptional cognitive abilities
Barral S, Singh J, Fagan E, Cosentino S, Andersen-Toomey SL, Wojczynski MK, Feitosa M, Kammerer CM, Schupf N; Long Life Family Study.
J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1683-1688. Pubmed abstract
Telomere length is longer in women with late maternal age
Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N.
Menopause. 2017 May;24(5):497-501. Pubmed abstract
The Survival of Spouses Marrying Into Longevity-Enriched Families
Pedersen JK, Elo IT, Schupf N, Perls TT, Stallard E, Yashin AI, Christensen K.
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):109-114. Pubmed abstract
Assortative mating by ethnicity in longevous families
Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT.
Front Genet. 2017 Nov 21;8:186. Pubmed abstract
Biomarker signatures of aging
Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT.
Aging Cell. 2017 Apr;16(2):329-338. Pubmed abstract
Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study
Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, Newman AB, Kammerer CM.
J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411-1416. Pubmed abstract
2016
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study
Druley TE, Wang L, Lin SJ, Lee JH, Zhang Q, Daw EW, Abel HJ, Chasnoff SE, Ramos EI, Levinson BT, Thyagarajan B, Newman AB, Christensen K, Mayeux R, Province MA.
BMC Geriatr. 2016 Apr 9;16:80. Pubmed abstract
Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study
Kulminski AM, Raghavachari N, Arbeev KG, Culminskaya I, Arbeeva L, Wu D, Ukraintseva SV, Christensen K, Yashin AI.
Biogerontology. 2016 Nov;17(5-6):893-905. Pubmed abstract
Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology
Sanders JL, Singh J, Minster RL, Walston JD, Matteini AM, Christensen K, Mayeux R, Borecki IB, Perls T, Newman AB.
J Am Geriatr Soc. 2016 Aug;64(8):1679-83. Pubmed abstract
Detection of Significant Groups in Hierarchical Clustering by Resampling
Sebastiani P, Perls TT.
Front Genet. 2016 Aug 8;7:144. Pubmed abstract
Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study
Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT.
J Am Geriatr Soc. 2016 Nov;64(11):e189-e194. Pubmed abstract
2015
Are members of long-lived families healthier than their equally long-lived peers? Evidence from the Long Life Family Study
Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):971-6. Pubmed abstract
Heritability of telomere length in a study of long-lived families
Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N.
Neurobiol Aging. 2015 Oct;36(10):2785-90. Pubmed abstract
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of heart, cancer, and neurodegenerative disorders: Insights on mechanisms from the Long Life Family Study
Kulminski A, Arbeev K, Culminskaya I, Ukraintseva S, Stallard E, Province M, Yashin AI.
Rejuvenation Res. 2015 Apr;18(2):128-35. Pubmed abstract
Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index
Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB.
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8. Pubmed abstract
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data
Pedersen JK, Skytthe A, McGue M, Honig LS, Franceschi C, Kirkwood TB, Passarino G, Slagboom PE, Vaupel JW, Christensen K.
Ann Epidemiol. 2015 Aug;25(8):569-574.e3. Pubmed abstract
Association of Aging-Related Endophenotypes With Mortality in 2 Cohort Studies: the Long Life Family Study and the Health, Aging and Body Composition Study
Singh J, Schupf N, Boudreau R, Matteini AM, Prasad T, Newman AB, Liu Y, Christensen K, Kammerer CM.
Am J Epidemiol. 2015 Dec 1;182(11):926-35. Pubmed abstract
Burden of disease variants in participants of the long life family study
Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P.
Aging (Albany NY). 2015 Feb;7(2):123-32. Pubmed abstract
2014
Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: The Long Life Family Study (LLFS)
An P, Miljkovic I, Thyagarajan B, Kraja AT, Daw EW, Pankow JS, Selvin E, Kao WH, Maruthur NM, Nalls MA, Liu Y, Harris TB, Lee JH, Borecki IB, Christensen K, Eckfeldt JH, Mayeux R, Perls TT, Newman AB, Province MA.
Metabolism. 2014 Apr;63(4):461-8. Pubmed abstract
Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly
Barral S, Cosentino S, Christensen K, Newman AB, Perls TT, Province MA, Mayeux R; for the Long Life Family Study.
JAMA Neurol. 2014 Dec;71(12):1514-9. Pubmed abstract
Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol
Feitosa MF, Wojczynski MK, Straka R, Kammerer CM, Lee JH, Kraja AT, Christensen K, Newman AB, Province MA, Borecki IB.
Front Genet. 2014 Jun 3;5:159. Pubmed abstract
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan
Kulminski AM, Arbeev KG, Culminskaya I, Arbeeva L, Ukraintseva SV, Stallard E, Christensen K, Schupf N, Province MA, Yashin AI.
PLoS Genet. 2014 Jan 30;10(1):e1004141. Pubmed abstract
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study
Lee JH, Cheng R, Honig LS, Feitosa M, Kammerer CM, Kang MS, Schupf N, Lin SJ, Sanders JL, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R.
Front Genet. 2014 Jan 17;4:310. eCollection 2013. Pubmed abstract
Heritability of and Mortality Prediction With a Longevity Phenotype: The Healthy Aging Index
Sanders JL, Minster RL, Barmada MM, Matteini AM, Boudreau RM, Christensen K, Mayeux R, Borecki IB, Zhang Q, Perls T, Newman AB.
J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):479-85. Pubmed abstract
Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis
Tan Q, B Hjelmborg JV, Thomassen M, Jensen AK, Christiansen L, Christensen K, Zhao JH, Kruse TA.
BMC Proc. 2014 Jun;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S82. Pubmed abstract
Genetic variants associated with lung function: the long life family study
Thyagarajan B, Wojczynski M, Minster RL, Sanders J, Barral S, Christiansen L, Barr RG, Newman A; CHARGE consortium, SpiroMeta consortium.
Respir Res. 2014 Nov 1;15(1):134. Pubmed abstract
2013
Personality factors in the Long Life Family Study
Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT.
J Gerontol B Psychol Sci Soc Sci. 2013 Sep;68(5):739-49. Pubmed abstract
Genome-wide association study of personality traits in the long life family study
Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT.
Front Genet. 2013 May 8;4:65. eCollection 2013. Pubmed abstract
Exceptional memory performance in the Long Life Family Study
Barral S, Cosentino S, Costa R, Andersen SL, Christensen K, Eckfeldt JH, Newman AB, Perls TT, Province MA, Hadley EC, Rossi WK, Mayeux R; for the Long Life Family Study.
Neurobiol Aging. 2013 Nov;34(11):2445-8. Pubmed abstract
Reduced prevalence of cognitive impairment in families with exceptional longevity
Cosentino S, Schupf N, Christensen K, Andersen SL, Newman A, Mayeux R.
JAMA Neurol. 2013 Jul 1;70(7):867-74. Pubmed abstract
Age validation in the long life family study through a linkage to early-life census records
Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T.
J Gerontol B Psychol Sci Soc Sci. 2013 Jul;68(4):580-5. Pubmed abstract
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children
Kulminski AM, Arbeev KG, Christensen K, Stallard E, Miljkovic I, Barmada M, Yashin AI.
J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):760-8. Pubmed abstract
Apolipoprotein E and familial longevity
Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi WK, Mayeux R.
Neurobiol Aging. 2013 Apr;34(4):1287-91. Pubmed abstract
Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study
Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT.
Front Public Health. 2013 Sep 30;1:38. Pubmed abstract
2012
Cognitive function in families with exceptional survival
Barral S, Cosentino S, Costa R, Matteini A, Christensen K, Andersen SL, Glynn NW, Newman AB, Mayeux R.
Neurobiol Aging. 2012 Mar;33(3):619.e1-7. Pubmed abstract
Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing
Ramos E, Levinson BT, Chasnoff S, Hughes A, Young AL, Thornton K, Li A, Vallania FL, Province M, Druley TE.
BMC Genomics. 2012 Dec 6;13:683. Pubmed abstract
2011
Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits
Kulminski AM, Arbeev KG, Christensen K, Mayeux R, Newman AB, Province MA, Hadley EC, Rossi W, Perls TT, Elo IT, Yashin AI.
Mech Ageing Dev. 2011 Apr;132(4):195-201. Pubmed abstract
Health and function of participants in the Long Life Family Study: A comparison with other cohorts
Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E.
Aging (Albany NY). 2011 Jan;3(1):63-76. Pubmed abstract
2010
Heritability estimates of endophenotypes of long and health life: the Long Life Family Study
Matteini AM, Fallin MD, Kammerer CM, Schupf N, Yashin AI, Christensen K, Arbeev KG, Barr G, Mayeux R, Newman AB, Walston JD.
J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1375-9. Pubmed abstract
"Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS)
Yashin AI, Arbeev KG, Kulminski A, Borecki I, Christensen K, Barmada M, Hadley E, Rossi W, Lee JH, Cheng R, Elo IT.
Mech Ageing Dev. 2010 Mar;131(3):215-22. Pubmed abstract
2009
A family longevity selection score: ranking sibships by their longevity, size, and availability for study
Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS.
Am J Epidemiol. 2009 Dec 15;170(12):1555-62. Pubmed abstract
2008
A novel sampling design to explore gene-longevity associations: the ECHA study
De Rango F, Dato S, Bellizzi D, Rose G, Marzi E, Cavallone L, Franceschi C, Skytthe A, Jeune B, Cournil A, Robine JM, Gampe J, Vaupel JW, Mari V, Feraco E, Passarino G, Novelletto A, De Benedictis G.
Eur J Hum Genet. 2008 Feb;16(2):236-42. Pubmed abstract