Research in the Ravnskjaer lab

Vi søger løbende forskere samt motiverede molekylærbiologi-, biomedicin- og computational biomedicine-studerende til projekter på alle niveauer.
Skriv til Kim Ravnskjaer (ravnskjaer@bmb.sdu.dk) hvis du er interesseret eller har spørgsmål til vores projekter.

We are always on the lookout for motivated scientists and students of molecular biology, biomedicine, computational biomedicine or similar at all levels.
If you are interested or have questions to our projects, please contact Kim Ravnskjaer (ravnskjaer@bmb.sdu.dk).

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The research in the Ravnskjaer lab focuses on vascular and perivascular plasticity in cardiometabolic disease

Obesity, diabetes, cardiovascular and steatotic liver disease are among the cardiometabolic diseases. Common hallmarks of these diseases include severe metabolic perturbation, inflammation, and microvascular dysfunction. Research in our lab is aimed at understanding the cells and interactions that shape the microenvironments and tissue function in health and disease. We believe that Insights into microvascular and perivascular plasticity will form the basis for better disease monitoring and of innovative solutions for restoring tissue function and integrity.

In our projects, we investigate how cells in tissues interact and undergo transitions during the progression and regression of cardiometabolic disease. We elucidate molecular disease mechanisms by applying advanced functional genomics, bioimaging, biochemical and physiological measurements in the study of patient biopsies and animal models. Key technologies include single-cell and spatially resolved multiomics, transgenic mouse models, viral gene delivery, and a host of bioimaging techniques. Our computational biology platform allows us to leverage large datasets to delineate the inherent complexity of cardiometabolic diseases and identify underlying gene regulatory networks.
 Current projects

• Gene regulatory networks in the progression and regression of human liver disease
• Cellular crosstalk and metabolic regulation in advanced cardiometoblic disease
• Perivascular GPCR signaling in healthy and fibrotic tissues
• Microvascular transport and barrier function in health and disease

Read more about the projects

• Gene regulatory networks in the progression and regression of human liver disease

• Cellular crosstalk and metabolic regulation in advanced cardiometoblic disease

• Perivascular GPCR signaling in healthy and fibrotic tissues

• Microvascular transport and barrier function in health and disease