From Molecule to Health: Unraveling the Mysteries of Fat

Why did you become a researcher?

In 9th grade and my early high school years, I had a passion for photography and even established myself as a freelance sports photographer. At one point, I was close to leaving high school to pursue this full-time. However, an inspiring biology teacher changed my trajectory entirely. Growing up in an academic family, I had an early appreciation for knowledge, but it wasn’t until I immersed myself in the biology curriculum during the last year of high school that I discovered my passion for the natural sciences. The complexity of life at a molecular level captivated me, and my teacher’s enthusiasm and depth of knowledge revealed how much there was to explore. That experience set me on the path to a career in research, driven by the same curiosity and wonder I felt back then.

What occupies you at the moment?

In our daily work we try to integrate advanced lipidomics and metabolomics with functional and genetic approaches to investigate lipid metabolism at a molecular level. We are very interested in using mass spectrometry imaging to understand the spatial distribution of lipids within tissues, which will allow us to visualize how specific lipid types are distributed between specific cell types and interact with cellular machinery. We hope that such approaches can identify harmful lipid accumulations and unravel the complex molecular mechanisms behind their toxic effects. By uncovering which lipids disrupt cellular function and why certain tissues are more susceptible to lipid-induced damage, we hope to improve the prediction of disease risk and ultimately promote better health outcomes.

Which question would you really like to find an answer to?

I am passionate about uncovering the complex roles of lipids in human health and disease. Our research centers on one major question: How do specific lipids influence cellular functions and, ultimately, our health? We believe that lipids are not simply building blocks of cell membranes or energy reserves; they are active players in regulating vital processes within the body. We seek to understand how these molecules impact metabolism and cellular signaling, particularly in relation to ectopic lipid deposits, fat stored in places like the liver and muscles, and how these deposits can lead to chronic conditions like type 2 diabetes and cardiovascular disease.

What is the biggest breakthrough in your field ever?

The biggest breakthrough in my field has been the discovery of insulin to treat diabetes. This has helped millions of lives worldwide and still does. Related to this, the discovery and application of incretins, particularly GLP-1 (glucagon-like peptide-1), has transformed the treatment of diabetes and obesity. GLP-1 analogs can control blood sugar and support weight management.

Recent advances in structural biology now allow us to predict and model the shapes of complex proteins and drug targets with unprecedented accuracy. These structural insights make it possible to design next-generation therapeutics that are highly specific to their targets, minimizing side effects and enhancing efficacy. In essence, we’re moving toward a new era in drug discovery, where researchers can tailor molecular therapies to directly address the underlying mechanisms of diseases, opening up possibilities for treating conditions that were previously difficult to manage.

How do you hope that others can benefit from your research?

I hope our research can provide new insights into how lipids function within the body, why some are harmful and why others are not. By understanding how specific lipids influence health at the cellular level, we hope to improve the ways we can predict disease risks and hopefully identify interventions tailored to an individual’s unique lipid profile. Besides the scientific achievements I also hope that through dedicated mentoring and nurturing I can inspire the next generations of scientists to pursue their curiosity, embrace challenges, and contribute to impactful discoveries and dissemination of science.

Which other research field fascinates you the most?

Beyond my own field, I'm deeply fascinated by neuropsychology, particularly how the brain shapes human behavior and the science behind habit formation. Understanding how neural processes influence our actions and how we can consciously reshape habits is intriguing. It’s incredible to think about how complex networks in the brain drive behavior, and I’m fascinated by the potential to harness this knowledge to improve well-being and mental resilience.

What do you have in your office, that most other people don’t?

In my office, you'll find a collection of books on the history of science—probably more than in most people's offices. I've always found it fascinating to understand the context in which scientific discoveries were made, the questions that drove earlier researchers, and how their findings have shaped the path to where we are today. These books remind me that science is as much about curiosity and persistence as it is about breakthroughs, and I draw a lot of inspiration from learning about the challenges and triumphs of those who came before us.

Who do you admire the most?

I admire people who channel their dedication, motivation, and talent into making a real difference—whether in society, sports, or science. One figure who stands out to me is William S. Knudsen, whose story is captured in the book One Dollar Man, which I read a few years ago. Knudsen began his journey as a bicycle smith in Copenhagen, emigrating to the United States with little to his name. Through sheer hard work and adaptability, he rose to become one of America's most influential business leaders. His journey from humble beginnings to achieving significant impact speaks to the power of resilience and vision. I deeply respect people like Knudsen who embrace challenges and, through their perseverance, bring about meaningful change. They remind me that it’s possible to start with very little and still accomplish something that leaves a lasting legacy.

What do you do when you are not researching?

When I'm not immersed in research, I like to stay active and pursue a range of hobbies that keep me moving. I enjoy playing padel tennis and golf, both of which give me a great mix of focus and physical activity. I’m also an avid recreational fisher; whenever I get the chance I go after sea trout around the coastlines of Funen and after halibut, wolf fish, and cod in northern Norway. And for a more intense workout, I take to the trails on my mountain bike. I find these activities keep me energized and provide a good balance to my work—they’re a great way to clear my mind and return to research with fresh perspectives.